Are hippocampal lesions sufficient to cause lasting amnesia?
نویسندگان
چکیده
A 57-year-old woman developed severe generalised amnesia following an embolic stroke. The amnesia persisted until her death nine months later. The left hemisphere had a large infarction of the medial temporal-occipital region, while the right showed only a small infarct limited to the posterior two-thirds of the hippocampus. If bilateral lesions are necessary for the production of permanent amnesia, the findings support the view that the hippocampus is itself a critical structure in the medial temporal diencephalic memory circuit.
منابع مشابه
Lesions of the hippocampal formation but not lesions of the fornix or the mammillary nuclei produce long-lasting memory impairment in monkeys.
A group of tasks sensitive to human amnesia were used to characterize the severity and duration of memory impairment in monkeys following bilateral damage to the hippocampal formation, fornix, or mammillary nuclei. Monkeys with hippocampal formation lesions (which included the hippocampus proper, dentate gyrus, subiculum, posterior entorhinal cortex, and much of the parahippocampal gyrus) exhib...
متن کاملRetrograde amnesia: neither partial nor complete hippocampal lesions in rats result in preferential sparing of remote spatial memory, even after reminding.
Many lesion experiments have provided evidence that the hippocampus plays a time-limited role in memory, consistent with the operation of a systems-level memory consolidation process during which lasting neocortical memory traces become established [see Squire, L. R., Clark, R. E., & Knowlton, B. J. (2001). Retrograde amnesia. Hippocampus 11, 50]. However, large lesions of the hippocampus at di...
متن کاملDamage limited to the hippocampal region produces long-lasting memory impairment in monkeys.
Research in humans and monkeys has demonstrated a system of anatomically related structures in the medial temporal lobe that is important for memory function. This system is comprised of the hippocampal region (i.e., the dentate gyrus, hippocampus proper and subicular complex) and the entorhinal, perirhinal, and parahippocampal cortices. While the hippocampal region has long been thought to be ...
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Patient RB (Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus, S. Zola-Morgan, L. R. Squire, and D. G. Amaral, 1986, J Neurosci 6:2950-2967) was the first reported case of human amnesia in which detailed neuropsychological analyses and detailed postmortem neuropathological analyses demonstrated that dama...
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ورودعنوان ژورنال:
- Journal of neurology, neurosurgery, and psychiatry
دوره 45 3 شماره
صفحات -
تاریخ انتشار 1982